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ea0092ps2-20-06 | Thyroid hormone receptors basic | ETA2023

A cardiac developmental defect prevents thyroid hormone-induced tachycardia in the syndrome of resistance to thyroid hormone alpha

Dore Riccardo , Christine Sentis Sarah , Oelkrug Rebecca , Krause Christin , Geiszler Cathleen , Pedaran Mehdi , Kirchner Henriette , Mittag Jens

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...

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ea0081p202 | Thyroid | ECE2022

Deiodinase Type I regulation in fatty liver disease

Lopez Alcantara Nuria , Geiszler Cathleen , Naujack Alison-Michelle , Chen Yingfu , Taege Natalie , Britsemmer Jan H. , Vinicius Monteiro De Assis Leonardo , Oster Henrik , Spranger Joachim , Wirth Eva , Nogueiras Ruben , Kirchner Henriette , Mittag Jens

Background and Aim: Hepatic thyroid hormone (TH) signalling plays an important role in onset and progression of liver diseases. Patients with altered thyroid hormone regulation in the liver, leading to a local hypothyroid, are at higher risk of developing non-alcoholic fatty liver disease (NAFLD). Treatment with thyroid hormones proved to be a promising therapy for these patients, slowing the progression of NAFLD to non-alcoholic steatohepatitis (NASH), a more advanced stage o...

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Endocrine Abstracts

A cardiac developmental defect prevents thyroid hormone-induced tachycardia in the syndrome of resistance to thyroid hormone alpha

Deiodinase Type I regulation in fatty liver disease

BiosciAbstracts